« In vitro methods are a powerful tool for describing and understanding changes in metabolic pathways involved in disease states. They are also one of the best ways to quantify these changes. Thus, it is possible to measure the activity of an enzyme, and not just its presence. We can also measure the concentration of a key metabolite, or even a cascade of important metabolites. »
Marc Conti, Membre du conseil scientifique BioQuanta
Mitoxis®is an in vitro platform based on a global analysis of the effects of a compound on cellular metabolism. Mitoxis® is a highly automated system, which enables very precise measurements. It enables:
- An in-depth exploration of the electron-transport chain.
- An in-depth characterization of the redox status of the cell.
- Complementary tests on the cellular energy state, inflammation, and cell death.
Mitoxis® is an integrative approach consisting of a large panel of assays which fulfil experimental needs from the discovery phase to post-market studies.
Mitoxis® addresses the experimental needs of the pharmaceutical and cosmetics industries. It can also be applied to the companies affected by REACH. Our highly accurate assay results makes the Mitoxis service a viable alternative to animal testing. It is unique in the world in terms of accuracy, reliability, flexible deployment, and degree of automation.
The high precision of Mitoxis® can reveal small variations in enzymatic activity that could be involved in a mid- to long-term toxicity. These small variations are not detectable with less precise systems.
The Mitoxis® service can be integrated into existing drug development processes as decision guidance. You can use the results for a go/no-go decision on HTS/HCS hits, optimize a lead, or even reposition an existing drug.
The Mitoxis® platform can greatly accelerate in vitro metabolic and pharmacology studies while reducing costs. Mitoxis® data can be used for predictive de-risking to avoid late-stage attrition scenarios, such as restrictions on use, or even withdrawal from the market.
The science team behind Mitoxis® advises and assists clients in selecting the relevant cell types, dosage parameters, and analyses. Clients can request raw data or a detailed analysis and interpretation.
Technical features
Decision guidance
List of assays |
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Check out the list of tests that make up the panel Mitoxis® (booklet US version) |
Volumes samples |
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See the list of samples used by Mitoxis® |
To learn more about Mitoxis®, discuss specific needs or request a quote This e-mail address is being protected from spambots. You need JavaScript enabled to view it .
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MitoxisFor pharmaceuticals
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Mitoxisfor cosmetics industry
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